Blocking the effect of rubral IL-6 relieves pathological pain induced by nerve injury, while intrarubral administration of exogenous IL-6 can dose-dependently evoke obvious tactile allodynia in naive rats, indicating that IL-6 yields a facilitatory effect in the maintenance of neuropathic pain (Ding et al., 2016; Yang et al., 2020). The gene discussed is IL6; the disease is injury.