Furthermore, using the same GDM model, we tested the effects of Lactobacillus and Bifidobacterium probiotic supplements on the concentrations of IL-6, TNF-α, NO, insulin, LDL-C, HDL-C, TC, and TG and estimated the value of HOMA-IR in the serum of GDM rats. This evidence concerns the gene IL6 and gestational diabetes.