HTLV-1 bZIP factor (HBZ) and Tax play a critical role in leukemogenesis of ATL, and double transgenic mice of HBZ and Tax in CD4+ T cells develop T-cell lymphoma (Zhao et al., 2014; Nosaka and Matsuoka, 2021). The gene discussed is CNTN2; the disease is T-cell non-Hodgkin lymphoma.