IHH and neoplasm: Liang et al. (2014) found that the IHH gene is transcriptionally downregulated by EBV-associated hypermethylation in gastric cancer cells infected with EBV. Downregulation of IHH increases cell growth and colony formation ability, suggesting a tumor-suppressive potential of IHH in EBV-related gastric cancer (Liang et al., 2014).