SOCS1 and skin basal cell carcinoma: In BCC and medulloblastoma, GLI1 and GLI2 (GLI1/2) directly activate the transcription of suppressor of cytokine signaling 1 (SOCS1) and reduce signal transducer and activator of transcription 1 (STAT1) phosphorylation, imposing a negative effect on Interferon (IFN)-γ/STAT1 signaling and anticancer immunity (Laner-Plamberger et al., 2013).