ZBP1 and infection: ZBP1 functions as crucial adaptor for RHIM-dependent activation of RIPK3-dependent necroptosis during MCMV (Upton et al., 2012) infection and has more recently been implicated in the induction of necroptosis by influenza (Thapa et al., 2016) as well as vaccinia virus (VACV) (Koehler et al., 2017).