The frequency of intracellular IL-10 expressing CD4+ suppressive T cells to HBV core peptides was higher in HBV infected individuals with OBI (0.12%), CHB (0.11%), or resolved infection (0.1%), respectively, than in HBV non-infected individuals (0.06%) (Figures 5A,B; P < 0.05). This evidence concerns the gene CD4 and infection.