As shown in Figure 1A, 17 genes (IL6, TP63, ELANE, NLRP1, PJVK, GSDME, NLRP3, NOD1, IL1B, CASP1, CASP4, CHMP3, SCAF11, GPX4, IRF2, TIRAP, and PLCG1) were downregulated while 21 genes (CASP8, CHMP6, GSDMB, CHMP4C, CHMP2A, CHMP2B, CYCS, CASP3, IRF1, CASP6, BAK1, GSDMD, GZMA, BAX, IL18, NLRP6, NOD2, PYCARD, AIM2, GSDMC, and NLRP7) were upregulated in tumor tissues. This evidence concerns the gene GSDMD and neoplasm.