NOD2 and neoplasm: As shown in Figure 1A, 17 genes (IL6, TP63, ELANE, NLRP1, PJVK, GSDME, NLRP3, NOD1, IL1B, CASP1, CASP4, CHMP3, SCAF11, GPX4, IRF2, TIRAP, and PLCG1) were downregulated while 21 genes (CASP8, CHMP6, GSDMB, CHMP4C, CHMP2A, CHMP2B, CYCS, CASP3, IRF1, CASP6, BAK1, GSDMD, GZMA, BAX, IL18, NLRP6, NOD2, PYCARD, AIM2, GSDMC, and NLRP7) were upregulated in tumor tissues.