As shown in Figure 1A, 17 genes (IL6, TP63, ELANE, NLRP1, PJVK, GSDME, NLRP3, NOD1, IL1B, CASP1, CASP4, CHMP3, SCAF11, GPX4, IRF2, TIRAP, and PLCG1) were downregulated while 21 genes (CASP8, CHMP6, GSDMB, CHMP4C, CHMP2A, CHMP2B, CYCS, CASP3, IRF1, CASP6, BAK1, GSDMD, GZMA, BAX, IL18, NLRP6, NOD2, PYCARD, AIM2, GSDMC, and NLRP7) were upregulated in tumor tissues. The gene discussed is CASP6; the disease is neoplasm.