GPER1 and cancer: The 11 genes in MCODE1 (CCR10, CXCL16, CXCL2, CXCL3, CXCL8, GPER1, NMU, SAA1, BDKRB2, CCL20, and CCL5) were associated with cell chemotaxis, which induced the directional migration of cells including cancer cells and immune cells (Buckner et al., 2014; AbdelMageed et al., 2019; Chen et al., 2019; Zhao Q. Q. et al., 2020).