CD4 and neoplasm: Previous studies proved that reprogramming of the tumor immune microenvironment was a valuable prognostic signature, such as a lack of T cells, microphage phenotype, the number of B cells, CD4+ T cells, CD8+ T cells, DC cells, and the ablation of eosinophils (Shankaran et al., 2001; Galon et al., 2006; Bindea et al., 2013; Herrera et al., 2013; Arnold et al., 2020; Petitprez et al., 2020).