The normal ovary tissues, benign ovarian tumors, and borderline ovarian tumors were studied to reveal that TLR4, NF-κBp65, and HIF-1α were expressed at a low level, while as cancer progressed, the proportion of the TLR4+ve, NF-κBp65+ve, and HIF-1α+ve EOC cells were significantly increased (Figure 1(a)). Here, HIF1A is linked to ovarian benign neoplasm.