MAPK8 and atherosclerosis: Since the Wnt/PCP-JNK pathway is closely associated with lipid metabolism, inflammation, and cell proliferation [31] and sFRP1 is known to regulate Wnt/PCP-JNK in cardiac myoblasts [32], we explored whether miR-1a-3p regulated the inflammation induced by atherosclerosis via sFRP1/Wnt/PCP-JNK signaling.