This alternative interpretation of the experimental evidence readily incorporates lipoprotein transcytosis and also takes into account the unique isolation of the vascular smooth muscle cells (VSMCs) in the avascular media layer [33], the involvement of medial VSMCs in the early stages of plaque formation and generation of foam cells [34], the involvement of SR-B1 in angiogenesis [35, 36], and the dependence of the murine apoE−/− model of atherosclerosis on vv neovascularization [37, 38]. Here, APOE is linked to atherosclerosis.