Moreover, in the context of LDL transcytosis, endothelial-specific manipulations of the SR-B1 expression create results that are contradictory and hard to interpret: whereas the endothelial-specific knockout of Scarb1 in apoE−/− mice reduces atherosclerosis [9] - ostensibly due to reduced LDL transcytosis-its endothelial - specific overexpression, on a similar apoE−/− background, is also antiatherogenic [7]. The gene discussed is APOE; the disease is atherosclerosis.