For the sake of further investigating RIP3's roles in cardiomyopathy, we generated several cardiomyocyte hypertrophy models on rats by aortic banding (AB) surgery and on neonatal rat cardiomyocytes (NRCMs) by angiotensin II (Ang-II) or phenylephrine (PE) treatment. Here, RIPK3 is linked to cardiomyopathy.