G3842A is a nonsense mutation in nicotinamide adenine dinucleotide hydride (NADH) dehydrogenase (ND) subunit 1 gene (ND1), which encodes a part of complex I. We previously identified this mutation in papillary thyroid carcinoma [18], and it has also been identified in follicular thyroid carcinoma (FTC) [15] and liver cancer [19], suggesting the pathogenicity of G3842A. The gene discussed is MT-ND1; the disease is thyroid gland papillary carcinoma.