GSTM1 and anemia: If anemia is severe (Hb < 7–8 g/dL), it should be treated with blood transfusion; if anemia is moderate (Hb 8–10 g/dL), it should be treated with ESAs; and if anemia is mild (Hb 10–12 g/dL), it should be treated with iron therapy or multivitamins.