Besides, in vitro study has demonstrated that human platelets have CB1 and CB2 receptors on the cell membrane, and delta-9-tetrahydrocannabinol (THC) may have pro-coagulatory effects on these receptors [24], which could lead to thrombosis of the coronary artery without any underlying stenosis or coagulation disorders as explained in some case reports [25]. Here, CNR1 is linked to blood coagulation disease.