TNF-α presents in the blood and lungs of patients with COVID-19 (244), and in severe COVID-19 cases, high systemic TNF-α levels were associated with respiratory distress syndrome (98, 245, 253, 254), and lower survival along with pulmonary dysfunction [edema, proteinaceous exudates, pneumocyte desquamation, and ARDS (66)] as well as impaired hematopoietic function, disseminated intravascular coagulation, debilitating hyperlipidemia, liver damage, chronic kidney disease, diabetes, and hypertension (8, 33, 77, 135, 255). This evidence concerns the gene TNF and chronic kidney disease.