Cytokine- or chemokine-specific clinical symptoms are as follows: elevated IFN-γ causes fever, headaches, chills, fatigue, malaise, cardiomyopathy, vascular leakage, lung injury, and acute-phase protein production; increased TNF-α causes flu-like symptoms (69, 106); and IL-6 overexpression induces cardiomyopathy and vascular leakage, and it activates the complement pathway, coagulation cascade, diffuse intravascular coagulation, and the cytokine storm (69, 82, 84, 85). This evidence concerns the gene IFNG and cardiomyopathy.