Mechanisms causing liver injury in patients with COVID-19 remain unclear; however, multiple theories have been postulated: (1) ACE2-mediated direct viral infection of gastrointestinal epithelial cells to dysregulate liver functions (351); (2) critical patient status and immune-mediated injuries, such as cytokine storm or pneumonia-associated hypoxia, or IL-6-mediated activation of the complement system and consequent increase in vascular permeability (364); and (3) drug hepatotoxicity (352). The gene discussed is IL6; the disease is COVID-19.