The PRRs, such as CD36, CD14, TLR2, RAGE, and P2X7R, of microglia are crucial in Aβ-triggered activation of the NLRP1 inflammasome (N1I) (14) and N3I (18), which causes IL-1β/IL-18/pyroptosis-mediated inflammation in mice and in AD patients (13). Here, NLRP1 is linked to Alzheimer disease.