established F344-Lewis rat CAD model to find that Sirt1 (58) and Sirt3 (59) were both decreased at 3 months after transplantation, and their expression negatively correlated with renal failure, inflammatory chemokines expression and interstitial fibrosis severity, suggesting that sirt1 and sirt3 may serve an important protective role in the early stage of CAD. Here, SIRT1 is linked to Renal insufficiency.