ACE2 and infection: Compared with immune sera from SARS-CoV-1 and MERS, which mainly depend on FcγR1 and FcγR2a for ADE of infection, ADE of infection by monoclonal antibodies against SARS-CoV-2 could be independent of FcγR (i.e., ACE2-dependent) or dependent on FcγR2b or FcγR1 (5, 37, 46).