Previous studies have shown that miR-18b can prevent cerebral ischemia-reperfusion injury by activating the PI3K/Akt pathway and inhibiting ANXA3 in an oxygen-glucose deprivation/reperfusion model (OGDR) in vitro and middle cerebral artery occlusion model (MCAO) in vivo simulating the cerebral ischemia-reperfusion injury (38). This evidence concerns the gene AKT1 and brain ischemia.