SPRY-IT1, HOTTIP, and ANCR were also correlated with mRSS: ANCR expression was related to disease duration, the presence of PH, and altered lipid profile in patients with SSc, TINCR was positively correlated with ESR; and SPRY4-IT1 was associated with the presence of PH (118). This evidence concerns the gene SPRY4 and systemic sclerosis.