CAFs of ATLL were separated into two subgroups: CAF/EGRhigh exhibited relatively higher expression of epidermal growth response (EGR) genes such as EGR1, EGR2, EGR3, and ICAM1, while CAF/EGRlow showed relatively lower expression of these genes (Figure 6C). This evidence concerns the gene EGR1 and adult T-cell leukemia/lymphoma.