In our cohort, at baseline, PD-1high CD4+ T cell frequencies were higher in LN patients compared with non-LN patients, with a trend towards a statistically significant difference (6.1 (4.0-8.6) vs 3.0 (1.5-5.3) % out of CD4+, p=0.055 (data not shown). The gene discussed is CD4; the disease is lobular neoplasia.