Expression comparison showed that IRF1/2/3/7/8/9/10 were significantly upregulated by SVCV infection in all five zebrafish tissues (gill, spleen, head kidney, body kidney and liver), and IRF4b/5/6/11 did not to respond to viral infection in certain tissues, such as IRF6 in liver, IRF5 and IRF11 in spleen, body kidney and liver (Figure 1A). This evidence concerns the gene IRF6 and viral infectious disease.