Keratinocytes can amplify the attraction and production of cytokines by various subsets of T cells through their release of chemokines, including CCL17, CCL22, CCL20, CCL27, CXCL9, CXCL10 and CXCL11 (73, 75, 105, 106), whose expression is increased in AD skin (15, 19, 107–112). This evidence concerns the gene CCL22 and Alzheimer disease.