In addition, Cyclocarya paliurus ameliorates hyperuricemia and gout via a mechanism that may involve 3β,23-dihydroxy-12-ene-28-ursolic acid, a potent substance derived from C. paliurus that inhibits NLRP3 inflammasome formation via PI3K/Akt/mTOR-dependent autophagy (86). The gene discussed is NLRP3; the disease is gout.