In this case, mirroring what happens during anemia, an increase in the expression of hamp1 would have an inhibitory effect on ferroportin, limiting its expression and membrane presence, and thus limiting iron release from liver hepatocytes, macrophages and intestinal enterocytes, as well as decreased iron uptake by the intestinal enterocytes (39–41). This evidence concerns the gene SLC40A1 and anemia (phenotype).