Furthermore, CXCL5/8 elevation has been found in the serum of MS patients; the interplay between serum CXCL5/8 and its BEC receptor CXCR2 can give rise to abnormal paraendothelial passage via Akt/protein kinase B by regulating the cytoskeleton and ZO-1 (118). The gene discussed is CXCL5; the disease is myeloid sarcoma.