Also, they showed that IL-10 and IFNγ regulate the IL-17 responses of peripheral blood mononuclear cells (PBMCs) from human patients with leishmaniasis In addition, although having better parasite clearance, the IL-10-/- mice displayed a loss of immunity to reinfection, suggesting a role of IL-10 in the maintenance of effector memory responses (207). This evidence concerns the gene IL10 and leishmaniasis.