In our study, scRNA-seq analysis and protein validation implicate the CCR2-CCL2, CCR5-CCL3/4/5, CXCR3-CXCL9, CXCR4-CXCL12, and CXCR6-CXCL16 chemokine axes, and CD49a, CD49d, and CD11a integrins in glioblastoma infiltration. Here, CXCR4 is linked to glioblastoma.