CD4 and glioblastoma: In contrast, CD49a (integrin α1) expression was significantly enriched within CD4+ Tcm, Tem, Temra and Tregs, and CD8+ Tcm, Tem and Temra subsets in glioblastoma infiltrates compared to blood, and both CD4+ and CD8+ Trm cells expressed this integrin (Figures 5C, D).