Meanwhile, we found that the top three negatively enriched pathways were Alzhemers disease, Huntingtons disease, Parkinsons disease, glutathione metabolism, and pyruvate metabolism (Figure 6B; P<0.01), while the top four positively enriched pathways were ABC transporters based on the KEGG terms (Figure 6C; P<0.05). This evidence concerns the gene ABCG2 and Huntington disease.