HMGB1 and metabolic dysfunction-associated steatohepatitis: For example, HMGB1 released by hepatocytes can activate KCs in Acetaminophen-induced liver injury (AILI), Non-alcoholic steatohepatitis (NASH), and I/R injury (82, 83).In liver diseases, KCs interact with other liver cells such as hepatocytes, cholangiocytes, LSECs, HSCs, and other immune cells.