The synergic regulatory mechanism of miR-959-962 cluster in the Drosophila immune response to M. luteus infection could negatively regulate the Toll pathway in combination via directly targeting the 3’UTR of the tube, dl, or Toll mRNAs, leading to a reduced survival rate of flies by inhibiting the expression of AMPs at the late stage of the infection (137). This evidence concerns the gene TLR4 and infection.