Assessment of serum parameters associated with endothelial activation and distress such as ANG2 (Angiopoietin-2), ST-2 (suppressor of tumorigenicity 2), sCD141 (soluble thrombomodulin), and IL8 (interleukin 8) could help to understand endothelial contribution to the pathogenesis of CRS/ICANS. The gene discussed is CXCL8; the disease is congenital rubella syndrome.