In contrast, marker values measured on day+7 were associated with severe CRS/ICANS occurring before or after day 7 for all four serum markers (ORs for doubling of marker values): ST2-d7 OR 2.9 (1.7–5.2), p < 0.001; ANG2-d7 OR 2.9 (1.5–5.2), p = 0.001; sCD141-d7 OR 13.4 (3.0–59.8), p = 0.001; IL-8-d7 OR 1.9 (1.2–2.9), p = 0.004 (Figure 4). This evidence concerns the gene ANGPT2 and congenital rubella syndrome.