TET2 and hydrops fetalis: Consistently, it has been suggested that hematopoietic or myeloid ten-eleven translocation 2 deficiency elevated IL-1β expression and enhanced TAC-induced cardiac remodeling and cardiac dysfunction, thus promoting the development of HF, which was rescued by MCC950, indicating that ten-eleven translocation 2 mediated HF via an IL-1β/NLRP3 inflammasome-dependent mechanism (123).