In consideration of the effect of the inflammasome in cardiac fibrosis, Chinese herbal medicine triptolide and active small molecule pirfenidone have been used to treat fibrosis and were shown to inhibit NLRP3 inflammasome activity, reduce macrophage infiltration and fibrosis, and improve TAC-induced cardiac diastolic and systolic functions (132, 133). The gene discussed is NLRP3; the disease is fibrosis.