CRP and hydrops fetalis: The efficacy of canakinumab in patients with AMI was studied in the multicenter Canakinumab Anti-Inflammatory Thrombosis Outcome Study (CANTOS) trial (143, 144) involving 10,061 patients with previous AMI (at least 30 days before enrollment) and elevated C-reactive protein (CRP) levels (>2 mg/L), which concluded that canakinumab at a dose of 150 mg significantly reduced the incidence of a recurrent cardiovascular event and hospitalizations for HF in patients with established atherosclerotic disease.