CD8A and lymphopenia: The patient's immunological phenotype included marked B cell lymphopenia with reduced pre-switch and switch memory B cells, decreased CD4<sup>+</sup> and CD8<sup>+</sup> naïve T cells, elevated CD4<sup>+</sup> and CD8<sup>+</sup> T<sub>EMRA</sub> cells, and abnormal T cell activation and proliferation.