Earlier studies have shown the incidence of hyper and demethylated CpG sites within COVID-19 patients: significant hypermethylation in regulatory regions of the genes related to the type I interferon response and first-line antiviral defense genes, like ISG20 and IFITM1, are associated with disease severity in COVID-19 patients (14). The gene discussed is IFITM1; the disease is COVID-19.