ACE2 and systemic lupus erythematosus: Another study observed that systemic lupus erythematosus (SLE) patients are more likely to develop SARS-CoV-2 symptoms, not because of a weakened immune system, but because of overexpression of ACE2 in the lung, and hypomethylation of the ACE2 gene, as well as a high level of demethylation of interferon genes (50).