Additionally, cognitive impairment induced by HCD can be partially reversed by treatment with a tannins-enriched fraction of Emblica officinalis, which exerts its anti-inflammatory effects by inhibiting NF-κB nuclear translocation (Husain et al., 2018c) and exerts its antioxidant stress effects by activating the Nrf2-ARE pathway (Husain et al., 2018b). Here, NFKB1 is linked to Cognitive impairment.