Furthermore, both studies of NrCAM-null mice and genomic association studies have linked NrCAM with impaired sociability, addiction and autism, conditions associated with hypothalamic dysfunction (Ishiguro et al., 2006, 2014, 2019; Sakurai et al., 2006; Moy et al., 2009; Sakurai, 2012). Here, NRCAM is linked to autism.