APOE and Alzheimer disease: APOE is the gene most associated with AD among other identified candidate genes, including the ATP binding cassette subfamily A member 7, bridging integrator 1, CD33 molecule, clusterin, complement C3b/C4b receptor 1, CD2-associated protein, ephrin type-A receptor 1, membrane-spanning 4-domains A6A-A4E, phosphatidylinositol-binding clathrin assembly protein, HLA class II histocompatibility antigen, DRB5 beta chain- DRB1 beta chain, sortilin-related receptor 1, fermitin family homolog 2, Cas scaffold protein family member 4, and protein tyrosine kinase 2 beta (Scheltens et al., 2016).