The GG and AG genotypes of the insulin-degrading enzyme (IDE) gene SNP rs2421943 may affect the rate of IDE pre-RNA (heterogeneous nuclear RNA, hnRNA) processing, resulting in slower translation, reduced IDE levels, insufficient removal of Aβ fragments, and increased risk and/or accelerated progression of AD (Šerý et al., 2022). The gene discussed is IDE; the disease is Alzheimer disease.