Unlike genetic causes and other risk factors, neuroinflammation is generally not considered to be the initial cause of AD but is more likely to be the result of one or more AD pathologies or associated risk factors, which increase AD severity by exacerbating the pathological processes of Aβ, tau proteins, and NFTs (Kinney et al., 2018; Paouri and Georgopoulos, 2019; Yang and Zhang, 2020). The gene discussed is MAPT; the disease is Alzheimer disease.