c-Met kinase is located at the intersection of numerous tumor signaling pathways (Organ and Tsao, 2011), so dysregulation of the HGF/c-Met signaling pathway is a driving factor for many cancers, promoting tumor growth, invasion, spread, and/or angiogenesis (Parikh and Ghate, 2018), and is also associated with adverse clinical effects and drug resistance of some approved targeted therapies (Eder et al., 2009). The gene discussed is MET; the disease is cancer.