c-Met kinase is located at the intersection of numerous tumor signaling pathways (Organ and Tsao, 2011), so dysregulation of the HGF/c-Met signaling pathway is a driving factor for many cancers, promoting tumor growth, invasion, spread, and/or angiogenesis (Parikh and Ghate, 2018), and is also associated with adverse clinical effects and drug resistance of some approved targeted therapies (Eder et al., 2009). This evidence concerns the gene HGF and neoplasm.