CRH and Anxiety: To list a few examples: OTRs expressed on serotonin (5-HT) terminals in the NAc are critical for social motivation (Dölen et al., 2013), OTR activation in the VTA is necessary for social reward in male and female Syrian hamsters (Borland et al., 2019), OT modulates HPA activity and CRH release via interaction with GABA-A receptors in the PVN (Smith et al., 2016), and OT binds to Mu opioid receptors as a positive allosteric modulator and directly influences anxiety-like behavior associated with chronic pain (Meguro et al., 2018; Miyano et al., 2021).