TNFSF11 and osteonecrosis: The area of osteonecrosis of the jaw with empty lacunae was 1.9 ± 3.9 mm2 in IgG and was significantly higher in anti-RANKL/Mel with 23.9 ± 10.5 mm2 in anti-RANKL/Mel (P < 0.001) (Figure 1(d)).