Regarding the impact of MR expressed in macrophages on organ damage, it has been reported that myeloid MR-deficient mice were protected against anti-GBM glomerulonephritis, mimicking the benefit of eplerenone, suggesting that macrophages are a key component of the MR-induced kidney damage (Tesch and Young, 2017). The gene discussed is NR3C2; the disease is glioblastoma.