E.g., miRNAs can aggravate or alleviate SA-AKI by regulating the expression of forkhead box O3 (FOXO3), neuropilin 1 (NRP1) and thrombospondin 2 (THBS2) (Shen et al., 2019a; Luo et al., 2020a; Wang et al., 2020b). The gene discussed is THBS2; the disease is acute kidney injury.