Moreover, the sensitivity of urinary miR-452 in detecting AKI in septic patients was significantly higher than that in urinary tissue inhibitor metalloproteinase-2 [TIMP2]* insulin-like growth factor binding protein-7 [IGFBP7], and urinary miR-452 was significantly positively correlated with SCr, suggested that urine miR-452 may be an effective biomarker for early detection of AKI in septic patients (Liu et al., 2020c). Here, TIMP2 is linked to acute kidney injury.