Few studies revealed that miR-21 exerts an anti-apoptosis effect, while its overexpression can inhibit pro-apoptotic signaling pathways phosphatase and tension homolog (PTEN)/Akt and PDCD4/nuclear factor-κB (NF-κB) in the kidney, thereby alleviating kidney injury caused by sepsis (Jia et al., 2015; Fu et al., 2017; Yang et al., 2018; Pan et al., 2019). The gene discussed is AKT1; the disease is Sepsis.