PVT1 and diabetes mellitus: Furthermore, in a separate study by Toraih et al., ANRIL and 3 additional circulating lncRNAs (RNCR2, MALAT1, and PVT1) did not show an association with DR progression or anti-VEGF therapy response, but the expression patterns of these lncRNAs demonstrated good diagnostic performance in differentiating DM from controls and DR (30).