Furthermore, in a separate study by Toraih et al., ANRIL and 3 additional circulating lncRNAs (RNCR2, MALAT1, and PVT1) did not show an association with DR progression or anti-VEGF therapy response, but the expression patterns of these lncRNAs demonstrated good diagnostic performance in differentiating DM from controls and DR (30). This evidence concerns the gene MIAT and diabetes mellitus.