INSL3 and Hernia: In female fetal mice, which have been genetically engineered to produce INSL3, it appears that besides causing a slight dislocation of the ovaries, INSL3 also induces abdominal hernia (51), suggesting that the INSL3/RXFP2 system may additionally be involved in aspects of the second inguino-scrotal phase of testis descent in the males.