During diabetes, excessive AGEs cause ECs dysfunction by binding to the receptor for advanced glycation end products (RAGE), resulting in endothelial cell permeability increase (80), eNOS activity inhibition (81), and the coagulation system impairment (82, 83), NADPH oxidative (NOX) and NF-kB activating (84–86). The gene discussed is NOS3; the disease is diabetes mellitus.