The KEGG pathway associated with core targets mostly involved chemical carcinogenesis-receptor, coronavirus disease-COVID-19, and AGE-RAGE signalling pathway in diabetic complications, measles, EGFR tyrosine kinase inhibitor resistance, Th17 cell differentiation, HIF-1 signalling pathway, hepatitis B, focal adhesion, proteoglycans in cancer, lipid and atherosclerosis, and human cytomegalovirus infection. This evidence concerns the gene RENBP and hepatitis B virus infection.