A review by Zhang and colleagues highlighted the possible role of variants in ASH1 Like Histone Lysine Methyltransferase (ASH1L) in the etiology of psychiatric disorders including TS, autism spectrum disorders and intellectual disability (Zhanget al. 2021).ASH1L encodes a histone-lysine N-methyltransferase specifically trimethylating Lysine 36 of histone H3 forming H3K36me3.De novo mutations in this gene mainly cause intellectual disability with autistic traits (Krummet al. 2015). The gene discussed is ASH1L; the disease is Intellectual disability.