CELSR3 and Timothy syndrome: The same study also identified rare compound heterozygous variants in cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) in one proband (Zhaoet al. 2020b).CELSR3 encodes the Cadherin EGF LAG seven-pass G-type receptor 3 that may have an important role in cell/cell signaling during nervous system formation and is one of the few genes significantly associated with TS using WES (Wanget al. 2018) (Willseyet al. 2017).