Activated platelets secrete platelet-derived growth factor (PDGF), platelet-activating factor (PAF), and vascular endothelial growth factor (VEGF) along with several other cytokines to promote the formation of tumor-related blood vessels and the degradation of extracellular matrix, which in turn enhance tumor growth and distant metastasis (64). The gene discussed is PCLAF; the disease is neoplasm.